Hydrophobically Modified Hydroxypropyl Methylcellulose in Rats
نویسندگان
چکیده
A six-month repeated-dose dermal toxicity study fo11owed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new ceLlulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats, Aqueous paste of HM-HPMC was applied to the skin ofrats once daily at dose levels up to 60 mg/kglday, which was the highest dose that could be administered, Items checked included general signs, urinalysis, hematology, ophthalmology, and histopathology. One rat died during the administration period owing to a malignant tumor in the hemopoietic system, which was not attributed to the test substance, Statistically significant differences were found in some test results, but those were not dose-dependent and were considered to be incidental or spontaneous, It was concluded that the test substance was not toxic upon chronic dermal administration at dose levels up to 60 mglkglday,
منابع مشابه
Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very ...
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